Before The Simpsons, Matt Groening drew cartoons for Apple computers.
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The janitor from Scrubs was originally a figment of J.D.'s imagination.
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Because of South Park’s Scientology episode, the Church of Scientology hired people to spy on Matt and Trey to find something on them to use for blackmail. The Church became frustrated when their investigation turned up nothing but the fact that they’re pretty normal people.
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While filming a guest appearance on Star Trek TNG, Stephen Hawking was taken on a tour of the USS Enterprise set. When he saw the Warp Core, he paused, and said “I’m working on that.”
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John Swartzwelder, a writer for the Simpsons, used to write episodes while sitting in a booth at a coffee shop "drinking copious amounts of coffee and smoking endless cigarettes". When California passed an anti-smoking law, he bought the diner booth and installed it in his house.
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